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Tirzepatide 5mg

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Tirzepatide for Weight Loss: How It Works, How to Use, and What to Expect

Tirzepatide is a prescription medication approved for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) who have at least one weight-related health issue, such as high cholesterol or high blood pressure. It should always be used together with a reduced-calorie diet and increased physical activity.

How Tirzepatide Supports Weight Loss

Tirzepatide (marketed as Zepbound for weight loss) is a dual GIP and GLP-1 receptor agonist. Its combined action provides several benefits for fat loss:

  • Reduces Appetite & Increases Fullness: Mimics natural gut hormones, helping you feel full faster and stay satisfied longer, which reduces calorie intake.

  • Slows Digestion: Food stays in your stomach longer, further decreasing hunger.

  • Reduces Food Cravings: May help reduce “food noise” and the urge for unhealthy snacks.

  • Targets Fat Loss: Most weight lost is from fat mass, as confirmed by clinical studies.

How to Use Tirzepatide

Tirzepatide is given as a once-weekly subcutaneous injection (under the skin) using a pre-filled pen.

  • Starting Dose: Usually 2.5 mg once weekly for 4 weeks.

  • Dose Escalation: The dose can be increased by 2.5 mg every 4 weeks, as directed by your doctor.

  • Maintenance Dose: Typical long-term doses are 5 mg, 10 mg, or 15 mg once weekly (maximum is 15 mg).

  • Injection Sites: Abdomen, thigh, or upper arm. Rotate sites with each injection.

  • Timing: Use on the same day each week, at any time, with or without food.

  • Missed Dose: Take as soon as you remember within 4 days. If more than 4 days have passed, skip and take your next dose on schedule. Never double-dose.

Storage Instructions

  • Refrigeration: Store unopened pens in the fridge (2°C–8°C / 36°F–46°F) in the original carton.

  • Do Not Freeze: If frozen, do not use.

  • Room Temperature: Pens can be kept at room temperature (up to 30°C / 86°F) for up to 21 days after removal from the fridge.

Important Safety and Usage Notes

  • Combine with Lifestyle Changes: For best results, pair tirzepatide with a reduced-calorie diet and increased exercise.

  • Long-Term Use: Continued use may be needed to maintain weight loss. Stopping the medication may lead to weight regain.

  • Expected Results: Clinical studies show average weight loss of 15%–21% of body weight over 72 weeks, depending on dose.

  • Common Side Effects: Nausea, vomiting, diarrhea, constipation, and stomach pain. These usually lessen over time.

  • Serious Risks & Contraindications:

    • Thyroid C-cell Tumors: Do not use if you or your family have a history of certain thyroid cancers (MTC, MEN2).

    • Pancreatitis: Not recommended for those with a history of pancreatitis.

    • Gallbladder & Kidney Issues: Can cause or worsen these conditions.

    • Serious Allergies: Possible, though rare.

    • Severe GI Disease: Not advised for those with serious stomach or intestinal problems.

    • Pregnancy & Breastfeeding: Not recommended.